Joey Boca (Kevin Kline) is the owner of a pizza parlor located in Tacoma, Washington and has been married to Rosalie (Tracey Ullman) for years. Rosalie is horrified to discover that Joey is a womanizer, and has been cheating on her for a long time. Rosalie doesn't want to allow Joey the pleasure of having every woman he wants, so she refuses divorce. Taking extreme measures, she enlists the help of her mother (Joan Plowright), and co-worker Devo (River Phoenix) to kill Joey in order to put an end to his infidelity. They also hire two incompetent, perpetually stoned hit-men (William Hurt and Keanu Reeves).